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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: A CXC chemokine that is found in the alpha granules of PLATELETS. The protein has a molecular size of 7800 kDa and can occur as a monomer, a dimer or a tetramer depending upon its concentration in solution. Platelet factor 4 has a high affinity for HEPARIN and is often found complexed with GLYCOPROTEINS such as PROTEIN C.,CSP: high molecular weight proteoglycan-platelet factor complex which is released from blood platelets by thrombin; acts as a mediator in the heparin-neutralizing capacity of the blood and plays a role in platelet aggregation.,NCI: Platelet factor-4 is a 70-amino acid CXC chemokine. It is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation an
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skos:inScheme |
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skos:broader |
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skos:narrower |
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skos-xl:prefLabel |
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skos-xl:altLabel |
umls-label:A0025137,
umls-label:A0061837,
umls-label:A0061891,
umls-label:A0067400,
umls-label:A0099949,
umls-label:A0102347,
umls-label:A0319763,
umls-label:A0538025,
umls-label:A0833926,
umls-label:A0833927,
umls-label:A10787806,
umls-label:A11799492,
umls-label:A11916750,
umls-label:A11918354,
umls-label:A11918355,
umls-label:A11919164,
umls-label:A12992458,
umls-label:A12992459,
umls-label:A12994869,
umls-label:A12994870,
umls-label:A12997270,
umls-label:A17879417,
umls-label:A17879418,
umls-label:A17903525,
umls-label:A17903526,
umls-label:A17951611,
umls-label:A17951612,
umls-label:A17951613,
umls-label:A18047550,
umls-label:A18047551,
umls-label:A18361583,
umls-label:A18556317,
umls-label:A18556318,
umls-label:A18649209,
umls-label:A7572946,
umls-label:A7573072,
umls-label:A7573073,
umls-label:A7582153,
umls-label:A7620534,
umls-label:A7620561,
umls-label:A7633629,
umls-label:A7635219,
umls-label:A7660740,
umls-label:A7668095
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R28423681,
http://linkedlifedata.com/resource/umls/relation/R28497513,
http://linkedlifedata.com/resource/umls/relation/R44026366,
http://linkedlifedata.com/resource/umls/relation/R64605882,
http://linkedlifedata.com/resource/umls/relation/R120414610,
http://linkedlifedata.com/resource/umls/relation/R120414611,
http://linkedlifedata.com/resource/umls/relation/R120414613,
http://linkedlifedata.com/resource/umls/relation/R120414614,
http://linkedlifedata.com/resource/umls/relation/R120414615,
http://linkedlifedata.com/resource/umls/relation/R120414616,
http://linkedlifedata.com/resource/umls/relation/R120414617,
http://linkedlifedata.com/resource/umls/relation/R120414618,
http://linkedlifedata.com/resource/umls/relation/R120414620,
http://linkedlifedata.com/resource/umls/relation/R120414622,
http://linkedlifedata.com/resource/umls/relation/R120414623,
http://linkedlifedata.com/resource/umls/relation/R120414624,
http://linkedlifedata.com/resource/umls/relation/R120414626,
http://linkedlifedata.com/resource/umls/relation/R120414627,
http://linkedlifedata.com/resource/umls/relation/R120414628,
http://linkedlifedata.com/resource/umls/relation/R120414630,
http://linkedlifedata.com/resource/umls/relation/R120414631,
http://linkedlifedata.com/resource/umls/relation/R120414632,
http://linkedlifedata.com/resource/umls/relation/R120414633,
http://linkedlifedata.com/resource/umls/relation/R120414634,
http://linkedlifedata.com/resource/umls/relation/R120414635,
http://linkedlifedata.com/resource/umls/relation/R120414636,
http://linkedlifedata.com/resource/umls/relation/R120414637,
http://linkedlifedata.com/resource/umls/relation/R120414638,
http://linkedlifedata.com/resource/umls/relation/R120414639,
http://linkedlifedata.com/resource/umls/relation/R120414640,
http://linkedlifedata.com/resource/umls/relation/R120414641,
http://linkedlifedata.com/resource/umls/relation/R120414642,
http://linkedlifedata.com/resource/umls/relation/R120414621,
http://linkedlifedata.com/resource/umls/relation/R120414625,
http://linkedlifedata.com/resource/umls/relation/R120414612
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