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MSH: Hydrolases that specifically cleave the peptide bonds found in PROTEINS and PEPTIDES. Examples of sub-subclasses for this group include EXOPEPTIDASES and ENDOPEPTIDASES.,PDQ: Enzymes produced and secreted by the pancreas which aid in the proteolysis of proteins in the digestive tract. Pancreatic proteolytic enzymes include trypsin, chymotrypsin and carboxypeptidase; these enzymes are secreted as zymogens, inactive precursors of the enzymes, and are activated in the lumen of the digestive canal. Another proteolytic enzyme, enteropeptidase, is associated with the brush border of enterocytes; this enzyme catalyses the conversion of trypsinogen into trypsin which, in turn, can activate a number of other pancreatic zymogens. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43492&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43492&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport
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umls-concept:C0207890,
umls-concept:C0002570,
umls-concept:C0030946,
umls-concept:C0038418,
umls-concept:C0117059,
umls-concept:C0070333,
umls-concept:C1454149,
umls-concept:C1259287,
umls-concept:C1259288,
umls-concept:C1611876,
umls-concept:C0052128,
umls-concept:C0076134,
umls-concept:C0541395,
umls-concept:C0650287,
umls-concept:C0656123,
umls-concept:C1870831,
umls-concept:C1957653,
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umls-concept:C0389404,
umls-concept:C1438277,
umls-concept:C0284707,
umls-concept:C1447019,
umls-concept:C0083300,
umls-concept:C0072501,
umls-concept:C0056151,
umls-concept:C0069594,
umls-concept:C0608765,
umls-concept:C0610260,
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umls-concept:C0052094,
umls-concept:C0052548,
umls-concept:C0053661,
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umls-concept:C0064293,
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umls-concept:C0065174,
umls-concept:C0065379,
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umls-concept:C0069559,
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umls-concept:C0072327,
umls-concept:C0072414,
umls-concept:C0072433,
umls-concept:C0072796,
umls-concept:C0074305,
umls-concept:C0074389,
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umls-concept:C0625336,
umls-concept:C0636458,
umls-concept:C0636538,
umls-concept:C0645089,
umls-concept:C0667050
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