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skos:definition |
MSH: Vitamin K-dependent calcium-binding protein synthesized by OSTEOBLASTS and found primarily in BONES. Serum osteocalcin measurements provide a noninvasive specific marker of bone metabolism. The protein contains three residues of the amino acid gamma-carboxyglutamic acid (Gla), which, in the presence of CALCIUM, promotes binding to HYDROXYAPATITE and subsequent accumulation in BONE MATRIX.,CSP: small acidic protein found in bone, dentin, calcified ectopic tissue, and plasma; comprises 1-2% of total bone protein, and has high Gla content.
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