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skos:definition |
MSH: An enediyne that alkylates DNA and RNA like MITOMYCIN does, so it is cytotoxic.,CSP: antitumor protein possessing a regulatory function on the metabolism of DNA; also a potent cytostatic agent active against gram-positive bacteria.,CHV: a kind of cancer treatment drug,PDQ: An enediyne antineoplastic antibiotic hybrid containing an aminoglycoside chromophore. Zinostatin is isolated from the bacterium Streptomyces carzinostaticus. The aminoglycoside component of zinostatin intercalates into DNA and the benzene diradical intermediate of the enediyne core binds to the minor groove of DNA, resulting in single- and double-strand breaks in DNA and apoptosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39510&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39510&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C682" NCI Thesaurus),NCI: An enediy
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