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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.,NCI: A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0006982,
umls-concept:C0025744,
umls-concept:C0051429,
umls-concept:C0066345,
umls-concept:C0163332,
umls-concept:C0591055,
umls-concept:C0591404,
umls-concept:C0618951,
umls-concept:C0623030,
umls-concept:C0718328,
umls-concept:C0718329,
umls-concept:C0729239,
umls-concept:C1563855,
umls-concept:C1563856,
umls-concept:C1563857,
umls-concept:C1563858,
umls-concept:C1563859,
umls-concept:C1829357,
umls-concept:C2936729
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skos-xl:prefLabel |
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skos-xl:altLabel |
umls-label:A0022172,
umls-label:A0085884,
umls-label:A0473202,
umls-label:A0473203,
umls-label:A0473276,
umls-label:A0473277,
umls-label:A0483835,
umls-label:A0483836,
umls-label:A0483837,
umls-label:A0483839,
umls-label:A0483840,
umls-label:A0563653,
umls-label:A10335830,
umls-label:A10339090,
umls-label:A10761556,
umls-label:A10767833,
umls-label:A10801324,
umls-label:A10808740,
umls-label:A10809166,
umls-label:A11562298,
umls-label:A11771246,
umls-label:A11904891,
umls-label:A12794690,
umls-label:A1305831,
umls-label:A17902964,
umls-label:A17902965,
umls-label:A17951052,
umls-label:A17951053,
umls-label:A17975328,
umls-label:A18022786,
umls-label:A18046985,
umls-label:A18046986,
umls-label:A18322535,
umls-label:A18592702,
umls-label:A18592703,
umls-label:A18629897,
umls-label:A18648492,
umls-label:A19015299,
umls-label:A8436438,
umls-label:A8481781
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R112184290,
http://linkedlifedata.com/resource/umls/relation/R01361845,
http://linkedlifedata.com/resource/umls/relation/R01361846,
http://linkedlifedata.com/resource/umls/relation/R01361847,
http://linkedlifedata.com/resource/umls/relation/R49862944,
http://linkedlifedata.com/resource/umls/relation/R55154505,
http://linkedlifedata.com/resource/umls/relation/R112186083,
http://linkedlifedata.com/resource/umls/relation/R32103968,
http://linkedlifedata.com/resource/umls/relation/R32103969,
http://linkedlifedata.com/resource/umls/relation/R44807973,
http://linkedlifedata.com/resource/umls/relation/R32103970,
http://linkedlifedata.com/resource/umls/relation/R44807972,
http://linkedlifedata.com/resource/umls/relation/R44807974,
http://linkedlifedata.com/resource/umls/relation/R44807975,
http://linkedlifedata.com/resource/umls/relation/R44807976,
http://linkedlifedata.com/resource/umls/relation/R44807977,
http://linkedlifedata.com/resource/umls/relation/R120366681,
http://linkedlifedata.com/resource/umls/relation/R120366682,
http://linkedlifedata.com/resource/umls/relation/R120366683,
http://linkedlifedata.com/resource/umls/relation/R120366685,
http://linkedlifedata.com/resource/umls/relation/R120366686,
http://linkedlifedata.com/resource/umls/relation/R120366687
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