| umls-concept:C0025241 | skos:definition | MSH: An alkylating nitrogen mustard that is used as an antineoplastic in the form of the levo isomer - MELPHALAN, the racemic mixture - MERPHALAN, and the dextro isomer - MEDPHALAN; toxic to bone marrow, but little vesicant action; potential carcinogen.,CSP: 4-bis-(2-chloroethyl)amino-L-phenylalanine; a bifunctional alkylating agent used as a DNA strand crosslinker and antineoplastic.,NCI: A drug that is used to treat multiple myeloma and ovarian epithelial cancer and is being studied in the treatment of other types of cancer. It belongs to the family of drugs called alkylating agents.,PDQ: An orally available phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA inter-strand cross-linkages, resulting in the inhibition of DNA and RNA synthesis and cytotoxicity against both dividing and non-dividing tumor cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42973&idtype=1" active clinical trials or " | lld:umls |
