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skos:definition |
MSH: An integrin alpha subunit of approximately 150-kDa molecular weight. It is expressed at high levels on monocytes and combines with CD18 ANTIGEN to form the cell surface receptor INTEGRIN ALPHAXBETA2. The subunit contains a conserved I-domain which is characteristic of several of alpha integrins.,NCI: Part of the integrin CR4, aka Complement Receptor 4, the CD11c/CD18 heterodimer. (Fundamental Immunology, 3rd ed., William Paul, ed., Raven Press, NY 1993, pg 927),NCI: Leukocyte Surface Antigen p150,95 has a unique alpha chain (CD11c) and shares a beta subunit (CD18) with two other members of the leukocyte adhesion molecule family. The alpha subunit has an extracellular domain containing ten potential glycosylation sites, a transmembrane domain, and a short cytoplasmic tail. It shows homology to alpha subunits of Platelet Glycoprotein IIb/IIIa, Vitronectin Receptor, and Fibronectin Receptor. Receptors involved in cell-cell and cell-matrix interactions belong to a superfamily of integrin genes. (from OMIM 15
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