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skos:definition |
MSH: Proteolytic enzymes from the serine endopeptidase family found in normal blood and urine. Specifically, Kallikreins are potent vasodilators and hypotensives and increase vascular permeability and affect smooth muscle. They act as infertility agents in men. Three forms are recognized, PLASMA KALLIKREIN (EC 3.4.21.34), TISSUE KALLIKREIN (EC 3.4.21.35), and PROSTATE-SPECIFIC ANTIGEN (EC 3.4.21.77).,NCI: Serine proteases that are found in many different tissues and fluids in the body. The kallikrein protease family is comprised of potent vasodilators and hypotensives agents, thus they play important roles in inflammation and blood pressure. These enzymes normally reside in the body as inactive prekallikreins, which are activated by Hageman factor.
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