isonicotinic acid hydrazide

Source:http://linkedlifedata.com/resource/umls/id/C0022209

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
calbc:hasCorrelation
skos:exactMatch
skos:definition
MSH: Antibacterial agent used primarily as a tuberculostatic. It remains the treatment of choice for tuberculosis.,CSP: antibacterial agent used primarily as a tuberculostatic.,CHV: Antibacterial agent used primarily as a tuberculostatic,CHV: Antibacterial agent used primarily as a tuberculostatic,PDQ: A synthetic derivative of nicotinic acid with anti-mycobacterial properties. Although its mechanism of action is still unclear, isoniazid appears to block the synthesis of mycolic acids, major components of the mycobacterial cell wall. This agent is only active against actively growing mycobacteria because, as a pro-drug, it requires activation in susceptible mycobacterial species. Isoniazid also interferes with mycobacterial metabolism of vitamin B6. Resistance occurs due to decreased bacterial wall penetration. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39484&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39484&idtype=1&closed=1" closed cli
skos:inScheme
skos:broader
skos:narrower
umls-concept:C0043643, umls-concept:C0063963, umls-concept:C0064048, umls-concept:C0064665, umls-concept:C0066090, umls-concept:C0066099, umls-concept:C0067133, umls-concept:C0071885, umls-concept:C0072702, umls-concept:C0074005, umls-concept:C0075315, umls-concept:C0075872, umls-concept:C0086317, umls-concept:C0141441, umls-concept:C0207495, umls-concept:C0254617, umls-concept:C0539004, umls-concept:C0601378, umls-concept:C0603711, umls-concept:C0609685, umls-concept:C0620241, umls-concept:C0631931, umls-concept:C0632929, umls-concept:C0641956, umls-concept:C0646377, umls-concept:C0702199, umls-concept:C0702200, umls-concept:C0702201, umls-concept:C0717871, umls-concept:C0723085, umls-concept:C0764487, umls-concept:C0769869, umls-concept:C1171531, umls-concept:C1172729, umls-concept:C1311433, umls-concept:C1436963, umls-concept:C1452679, umls-concept:C1567245, umls-concept:C1602521, umls-concept:C1602524, umls-concept:C1694794, umls-concept:C1722363, umls-concept:C1743956, umls-concept:C1744420, umls-concept:C1956612, umls-concept:C2714076, umls-concept:C2975823, umls-concept:C3252750
skos-xl:prefLabel
skos-xl:altLabel
More...