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skos:definition |
CSP: found on the surface membrane of basophils and mast cells in all individuals; may play a role in active immunity to helminthic parasites but in developed countries it is more commonly associated with immediate hypersensitivity diseases such as asthma and hay fever.,MSH: An immunoglobulin associated with MAST CELLS. Overexpression has been associated with allergic hypersensitivity (HYPERSENSITIVITY, IMMEDIATE).,CHV: a kind of antibody that plays an important role in allergy,CHV: a kind of antibody that plays an important role in allergy,CHV: a kind of antibody that plays an important role in allergy,NCI: An immunoglobulin isotype (subclass). This isotype has the unique ability to bind with high affinity to IgE receptors (FceRI) on mast cells and basophils and induce degranulation and cytokine production by these cells when they are crosslinked by antigen. In addition to a central role in atopy and allergic responses, it has been speculated that IgE-mediated mast cell degranulation, by its release of media
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