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skos:definition |
MSH: A congenital or acquired condition of insufficient production of ALDOSTERONE by the ADRENAL CORTEX leading to diminished aldosterone-mediated synthesis of Na(+)-K(+)-EXCHANGING ATPASE in renal tubular cells. Clinical symptoms include HYPERKALEMIA, sodium-wasting, HYPOTENSION, and sometimes metabolic ACIDOSIS.,CSP: aldosterone deficiency, usually associated with hypoadrenalism and characterized by hypotension, dehydration, and a tendency to excrete excessive amounts of sodium.
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