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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.,CSP: ribonucleotide reductase inhibitor which thereby lowers intracellular dNTP pools and slows DNA replication and repair; used as antineoplastic, cell devision inhibitor, and possible chemotherapy for sickle cell anemia.,NCI: An anticancer drug that belongs to the family of drugs called antimetabolites.,PDQ: A monohydroxyl-substituted urea (hydroxycarbamate) antimetabolite. Hydroxyurea selectively inhibits ribonucleoside diphosphate reductase, an enzyme required to convert ribonucleoside diphosphates into deoxyribonucleoside diphosphates, thereby preventing cells from leaving the G1/S phase of the cell cycle. This agent also exhibits radiosensitizing activity by maintaining cells in the radiation-sensitive G1 phase and interfering with DNA repair. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=40685&idtype=1" active clinical trials or "http://www.cancer.gov/Search/Clin
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0054633,
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umls-concept:C1528469,
umls-concept:C1528471,
umls-concept:C2355482
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skos-xl:prefLabel |
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R112185633,
http://linkedlifedata.com/resource/umls/relation/R01361466,
http://linkedlifedata.com/resource/umls/relation/R49862782,
http://linkedlifedata.com/resource/umls/relation/R55154359,
http://linkedlifedata.com/resource/umls/relation/R112185648,
http://linkedlifedata.com/resource/umls/relation/R32102673,
http://linkedlifedata.com/resource/umls/relation/R32102674,
http://linkedlifedata.com/resource/umls/relation/R120326454,
http://linkedlifedata.com/resource/umls/relation/R120326455,
http://linkedlifedata.com/resource/umls/relation/R120326456,
http://linkedlifedata.com/resource/umls/relation/R120326458,
http://linkedlifedata.com/resource/umls/relation/R120326459,
http://linkedlifedata.com/resource/umls/relation/R120326460,
http://linkedlifedata.com/resource/umls/relation/R120326461,
http://linkedlifedata.com/resource/umls/relation/R120326462,
http://linkedlifedata.com/resource/umls/relation/R120326463,
http://linkedlifedata.com/resource/umls/relation/R120326464,
http://linkedlifedata.com/resource/umls/relation/R120326465,
http://linkedlifedata.com/resource/umls/relation/R120326467,
http://linkedlifedata.com/resource/umls/relation/R120326468,
http://linkedlifedata.com/resource/umls/relation/R120326469,
http://linkedlifedata.com/resource/umls/relation/R120326471,
http://linkedlifedata.com/resource/umls/relation/R120326472
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