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skos:definition |
MSH: Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.,CSP: cells artificially created by fusion of activated lymphocytes with neoplastic cells; the resulting hybrid cells are cloned and produce pure or monoclonal antibodies or T-cell products, identical to those produced by the immunologically competent parent, and continually grow and divide as the neoplastic parent.,NCI: A tumor of hybrid cells used in the in vitro production of specific monoclonal antibodies; produced by fusion of an established tissue culture line of lymphocyte tumor cells (e.g., mouse plasmacytoma cells) and specific antibody-producing cells (e.g., splenocytes from specifically immunized mice); fusions are accomplished by use of polyethylene glycol or other methods.
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