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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: A lipid-regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol. These decreases occur primarily in the VLDL fraction and less frequently in the LDL fraction. Gemfibrozil increases HDL subfractions HDL2 and HDL3 as well as apolipoproteins A-I and A-II. Its mechanism of action has not been definitely established.,CSP: lipid regulating agent that lowers elevated serum lipids primarily by decreasing serum triglycerides with a variable reduction in total cholesterol.,NCI: A fibric acid derivative with hypolipidemic effects. Gemfibrozil interacts with peroxisome proliferator-activated receptors (PPARalpha) resulting in PPARalpha-mediated stimulation of fatty acid oxidation and an increase in lipoprotein lipase (LPL) synthesis. This enhances triglyceride-rich lipoprotein clearance and reduces the expression of apolipoprotein C-III (apoC-III). The reduction in hepatic production of apoC-III results in subsequent reduction of s
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skos:inScheme |
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skos:broader |
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skos:narrower |
umls-concept:C0055689,
umls-concept:C0070248,
umls-concept:C0299192,
umls-concept:C0700003,
umls-concept:C0720593,
umls-concept:C0730854,
umls-concept:C0733860,
umls-concept:C1567522,
umls-concept:C1567523,
umls-concept:C1567524,
umls-concept:C1567525,
umls-concept:C1567526,
umls-concept:C1567527,
umls-concept:C1567528,
umls-concept:C1567529,
umls-concept:C1567530,
umls-concept:C1567531,
umls-concept:C1567532,
umls-concept:C1567533,
umls-concept:C1567534,
umls-concept:C1567535,
umls-concept:C1567536,
umls-concept:C1567537,
umls-concept:C1567538,
umls-concept:C1567539,
umls-concept:C1567540,
umls-concept:C1567608,
umls-concept:C1567609,
umls-concept:C1567610,
umls-concept:C1567611,
umls-concept:C1567612,
umls-concept:C1567613,
umls-concept:C3490481,
umls-concept:C3490482
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skos-xl:prefLabel |
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skos-xl:altLabel |
umls-label:A0062383,
umls-label:A0555269,
umls-label:A0574783,
umls-label:A0829473,
umls-label:A0829475,
umls-label:A0829476,
umls-label:A10335436,
umls-label:A10770107,
umls-label:A11559843,
umls-label:A11770585,
umls-label:A11774499,
umls-label:A12800223,
umls-label:A17123745,
umls-label:A17878109,
umls-label:A17926459,
umls-label:A17998370,
umls-label:A17998371,
umls-label:A18022047,
umls-label:A18046214,
umls-label:A18283323,
umls-label:A18572905,
umls-label:A18684355,
umls-label:A7570733,
umls-label:A8436764,
umls-label:A8481666
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R01361356,
http://linkedlifedata.com/resource/umls/relation/R49862740,
http://linkedlifedata.com/resource/umls/relation/R55154317,
http://linkedlifedata.com/resource/umls/relation/R112185468,
http://linkedlifedata.com/resource/umls/relation/R32108691,
http://linkedlifedata.com/resource/umls/relation/R32108692,
http://linkedlifedata.com/resource/umls/relation/R44808654,
http://linkedlifedata.com/resource/umls/relation/R44808655,
http://linkedlifedata.com/resource/umls/relation/R44808656,
http://linkedlifedata.com/resource/umls/relation/R44808657,
http://linkedlifedata.com/resource/umls/relation/R44808658,
http://linkedlifedata.com/resource/umls/relation/R44808659,
http://linkedlifedata.com/resource/umls/relation/R44808660,
http://linkedlifedata.com/resource/umls/relation/R44808661,
http://linkedlifedata.com/resource/umls/relation/R44808662,
http://linkedlifedata.com/resource/umls/relation/R44808663,
http://linkedlifedata.com/resource/umls/relation/R44808664,
http://linkedlifedata.com/resource/umls/relation/R44808665,
http://linkedlifedata.com/resource/umls/relation/R44808666,
http://linkedlifedata.com/resource/umls/relation/R44808667,
http://linkedlifedata.com/resource/umls/relation/R44808668,
http://linkedlifedata.com/resource/umls/relation/R44808669,
http://linkedlifedata.com/resource/umls/relation/R44808670,
http://linkedlifedata.com/resource/umls/relation/R44808671,
http://linkedlifedata.com/resource/umls/relation/R44808672
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