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skos:definition |
MSH: Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA.,NCI: Integrin alpha-IIb/beta3 is a protein complex comprised of a heterodimer of integrin alpha 2b and integrin beta 3. This complex is involved in cell adhesion and blood clot formation.
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