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rdf:type |
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calbc:hasCorrelation |
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skos:exactMatch |
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skos:definition |
MSH: One of the cytotoxic dihalohexitols that may have alkylating antineoplastic activity. It causes bone marrow toxicity. The active form is thought to be the diepoxide.,PDQ: A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39215&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39215&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C425" NCI Thesaurus),NCI: A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. (NCI04)
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skos:inScheme |
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skos:broader |
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skos:narrower |
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skos-xl:prefLabel |
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R32100463,
http://linkedlifedata.com/resource/umls/relation/R120262033,
http://linkedlifedata.com/resource/umls/relation/R120262034,
http://linkedlifedata.com/resource/umls/relation/R120262035,
http://linkedlifedata.com/resource/umls/relation/R120262037,
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http://linkedlifedata.com/resource/umls/relation/R120262039,
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http://linkedlifedata.com/resource/umls/relation/R120262042,
http://linkedlifedata.com/resource/umls/relation/R120262043,
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http://linkedlifedata.com/resource/umls/relation/R120262047,
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http://linkedlifedata.com/resource/umls/relation/R120262051,
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http://linkedlifedata.com/resource/umls/relation/R120262056,
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http://linkedlifedata.com/resource/umls/relation/R120262058,
http://linkedlifedata.com/resource/umls/relation/R120262059,
http://linkedlifedata.com/resource/umls/relation/R120262045,
http://linkedlifedata.com/resource/umls/relation/R120262036,
http://linkedlifedata.com/resource/umls/relation/R120262049,
http://linkedlifedata.com/resource/umls/relation/R71313381,
http://linkedlifedata.com/resource/umls/relation/R28122367,
http://linkedlifedata.com/resource/umls/relation/R128805591,
http://linkedlifedata.com/resource/umls/relation/R128805590,
http://linkedlifedata.com/resource/umls/relation/R71151358,
http://linkedlifedata.com/resource/umls/relation/R119413249,
http://linkedlifedata.com/resource/umls/relation/R60458593,
http://linkedlifedata.com/resource/umls/relation/R22539388,
http://linkedlifedata.com/resource/umls/relation/R22539387,
http://linkedlifedata.com/resource/umls/relation/R22539389,
http://linkedlifedata.com/resource/umls/relation/R60455801,
http://linkedlifedata.com/resource/umls/relation/R54180453,
http://linkedlifedata.com/resource/umls/relation/R54180454,
http://linkedlifedata.com/resource/umls/relation/R54180455
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