Source:http://linkedlifedata.com/resource/umls/id/C0011967
MSH: One of the cytotoxic dihalohexitols that may have alkylating antineoplastic activity. It causes bone marrow toxicity. The active form is thought to be the diepoxide.,PDQ: A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39215&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39215&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C425" NCI Thesaurus),NCI: A bifunctional hexitol derivative with potential antineoplastic activity. Dianhydrogalactitol alkylates and cross-links DNA via an epoxide group during all phases of the cell cycle, resulting in disruption of DNA function and cell cycle arrest. (NCI04)