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skos:definition |
MSH: An alkaloid isolated from Colchicum autumnale L. and used as an antineoplastic.,NCI: A colchicine analog with potential antimitotic and antineoplastic activities. Demecolcine acid binds to the colchicine-binding site of tubulin, inhibiting its polymerization into microtubules, causing cell cycle arrest at metaphase and preventing cell division.
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