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rdf:type |
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MSH: A sulfone active against a wide range of bacteria but mainly employed for its actions against MYCOBACTERIUM LEPRAE. Its mechanism of action is probably similar to that of the SULFONAMIDES which involves inhibition of folic acid synthesis in susceptible organisms. It is also used with PYRIMETHAMINE in the treatment of malaria. (From Martindale, The Extra Pharmacopoeia, 30th ed, p157-8),CSP: USP lists as a suppressant of dermatitis herpetiformis.,PDQ: A synthetic derivative of diamino-sulfone with anti-mycobacterial and anti-malarial properties. A structural analog of p-aminobenzoic acid (PABA), dapsone inhibits dihydropteroate synthase (DHPS), an enzyme important in folate synthesis, resulting in a depletion of the folate pool and a reduction in the amount of thymidylate available for DNA synthesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=494629&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=494629&idtype=1&closed=1" closed clinical
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umls-concept:C1652085,
umls-concept:C1957158
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