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skos:definition |
CSP: bacterial enzyme which detoxifies the antibiotic chloramphenicol the gene therefore confers chloramphenicol resistance, which can be used as a marker or selector in genetic transfection experiments.,MSH: An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.,NCI: Bacterial chloramphenicol-O-acetyltransferase protein (219 aa, 26 kD) is encoded by the bacterial chloramphenicol-O-acetyltransferase (cat) gene. This enzyme detoxifies the antibiotic chloramphenicol via acetylation to yield chloramphenicol 3-acetate. The presence of this enzyme confers chloramphenicol resistance to bacteria, which is used as a marker for selection in molecular techniqu
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