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skos:definition |
MSH: A cell-cycle phase nonspecific alkylating antineoplastic agent. It is used in the treatment of brain tumors and various other malignant neoplasms. (From Martindale, The Extra Pharmacopoeia, 30th ed, p462) This substance may reasonably be anticipated to be a carcinogen according to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (From Merck Index, 11th ed),CSP: cell cycle phase nonspecific alkylating antineoplastic agent used in the treatment of brain tumors and various other cancers.,NCI: An anticancer drug that belongs to the family of drugs called alkylating agents.,CHV: a kind of cancer treatment drug,CHV: a kind of cancer treatment drug,PDQ: An antineoplastic nitrosourea. Carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. This agent also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-br
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