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skos:definition |
MSH: An enzyme that catalyzes the desaturation (aromatization) of the ring A of C19 androgens and converts them to C18 estrogens. In this process, the 19-methyl is removed. This enzyme is membrane-bound, located in the endoplasmic reticulum of estrogen-producing cells of ovaries, placenta, testes, adipose, and brain tissues. Aromatase is encoded by the CYP19 gene, and functions in complex with NADPH-FERRIHEMOPROTEIN REDUCTASE in the cytochrome P-450 system.,CSP: nonEC; cytochrome P450-like enzyme which, with an NADPH-linked reductase, catalyzes the oxidative aromatization of androgens to estrogens in the placenta, ovary, and testis, and at lower levels throughout the body.,NCI: A p450-like enzyme, Aromatase catalyzes, with an NADPH-linked reductase, the oxidative aromatization of androgens to estrogens. Expressed in gonads, palcenta and brain, Aromatase and NADPH-cytochrome P450 reductase (reductase) are both highly conserved, essential components of the enzyme complex and essential for reproductive developme
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