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rdf:type |
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MSH: Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects.,PDQ: An aminoacridine derivative with potent antineoplastic properties. Although its mechanism of action is incompletely defined, amsacrine may intercalate into DNA and inhibit topoisomerase II, resulting in DNA double-strand breaks. This agent's cytotoxicity is maximal during the S phase of the cell cycle when topoisomerase levels are greatest. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39142&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39142&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/Concept
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skos:inScheme |
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umls-concept:C0028540,
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umls-concept:C1523988,
umls-concept:C2607293
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umls:relation |
http://linkedlifedata.com/resource/umls/relation/R28410542,
http://linkedlifedata.com/resource/umls/relation/R112184225,
http://linkedlifedata.com/resource/umls/relation/R112184341,
http://linkedlifedata.com/resource/umls/relation/R112184342,
http://linkedlifedata.com/resource/umls/relation/R32097795,
http://linkedlifedata.com/resource/umls/relation/R32097796,
http://linkedlifedata.com/resource/umls/relation/R32097797,
http://linkedlifedata.com/resource/umls/relation/R32097798,
http://linkedlifedata.com/resource/umls/relation/R32097799,
http://linkedlifedata.com/resource/umls/relation/R32097800,
http://linkedlifedata.com/resource/umls/relation/R120191438,
http://linkedlifedata.com/resource/umls/relation/R120191439,
http://linkedlifedata.com/resource/umls/relation/R120191440,
http://linkedlifedata.com/resource/umls/relation/R120191442,
http://linkedlifedata.com/resource/umls/relation/R120191443,
http://linkedlifedata.com/resource/umls/relation/R120191444,
http://linkedlifedata.com/resource/umls/relation/R120191445,
http://linkedlifedata.com/resource/umls/relation/R120191446,
http://linkedlifedata.com/resource/umls/relation/R120191447,
http://linkedlifedata.com/resource/umls/relation/R120191448,
http://linkedlifedata.com/resource/umls/relation/R120191449,
http://linkedlifedata.com/resource/umls/relation/R120191451
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