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rdf:type |
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lifeskim:mentions |
umls-concept:C0025202,
umls-concept:C0027984,
umls-concept:C0030705,
umls-concept:C0039194,
umls-concept:C0085358,
umls-concept:C0441771,
umls-concept:C0441915,
umls-concept:C0680730,
umls-concept:C1148554,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1515926,
umls-concept:C1515946,
umls-concept:C1522326,
umls-concept:C1522577,
umls-concept:C1706438,
umls-concept:C2698600
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pubmed:issue |
12
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pubmed:dateCreated |
1999-10-5
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|
pubmed:abstractText |
The development of effective adjuvant therapies for the treatment of high-risk melanoma patients is critical for the prevention of metastatic disease and improvement of patient survival. Active specific immunotherapy has been tested as an adjuvant treatment in numerous clinical trials with overall limited, but occasionally promising, success rates. Newcastle disease virus (NDV) oncolysate has been utilized as an adjunctive immunotherapeutic agent in the postsurgical management of these patients. A phase II study initiated in 1975 using adjuvant vaccine therapy composed of allogeneic and autologous human melanoma cells infected with live NDV (NDV oncolysate) in patients with AJCC stage III melanoma following therapeutic lymph node dissection has shown >60% survival rate at 10 years with no adverse effects. Continued long-term analysis of trials with promising early results as well as assessment of immunologic responses generated in these patients may result in improved therapeutic decisions for clinical trials in the future.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-1342060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-14308233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-1656442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-1663989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-1805813,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-1829908,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-1833503,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-1953101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-196739,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-2418935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-2459402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-3065642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-6800589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-7092355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-7212800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-7387358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-7538544,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8040891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8164027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8169112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8211163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8228260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8235605,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8248131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8348563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8496418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8516615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8529128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8558223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8673692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-8673695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-879870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-9045874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-9121184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-9161800,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-9196151,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-9378560,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9990864-9816311
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1076-1551
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
783-94
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
|
