Linked Life Data

9949806

Source:http://linkedlifedata.com/resource/pubmed/id/9949806

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-3-2
pubmed:abstractText
An appropriate T helper (Th) 1 immune response is required for the elimination of Mycobacterium tuberculosis. The factors regulating the polarization of mouse or human T cells to produce Th1 or Th2 cytokines are briefly reviewed. These factors include host genetics, cytokines present at the site of T cell activation, the type, dose and localization of antigen, the type of antigen-presenting cells, the engagement of different costimulatory molecules, steroid hormones and age. T cells of children produce low levels of gamma-interferon and we hypothesize that this may partly explain the differences in the clinical manifestations of tuberculosis in children and adults. Given that Th2 cytokines inhibit Th1 responses, the question arises of whether individuals mounting prominent Th2 responses, manifested by high serum IgE levels, are more susceptible to M. tuberculosis. In a community with a high incidence of tuberculosis, serum IgF levels, a marker of prominent Th2 responses, correlate with disease incidence and with socioeconomic deprivation. We propose that Th2 immune dominance, probably induced by intestinal parasites, enhances susceptibility to tuberculosis. Furthermore, our finding that serum IgE declines in patients following active tuberculosis argues that tuberculosis down-regulates Th2 responses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1528-2511
pubmed:author
pubmed:issnType
Print
pubmed:volume
217
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
145-57; discussion 157-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Signals that regulate the host response to Mycobacterium tuberculosis.
pubmed:affiliation
MRC Centre for Molecular and Cellular Biology, Faculty of Medicine, University of Stellenbosch, Tygerberg, South Africa.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't