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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1999-3-1
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pubmed:abstractText |
Th1 cell-induced anti-mycobacterial immunity is lost during a progressive Mycobacterium tuberculosis infection in a susceptible host. This study was designed to test the mechanism of the loss of anti-mycobacterial cell-mediated immune response. We demonstrate that M. tuberculosis infection results in increased Fas expression and decreased Bcl-2 expression in CD4+ T cells. When CD4+ T cells are stimulated in vitro, they show increased apoptosis and decreased production of IL-2 and interferon-gamma (IFN-gamma) but not of IL-4. These changes may result in selective apoptosis of Th1-like cells, leading to the loss of cell-mediated immune response against M. tuberculosis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-1372208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-1509256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-2419430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-2531194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-2939169,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-6982763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-7493639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-7504064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-7525297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-7530335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-7566090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-7612233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-8088331,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-8125515,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-8245795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-8501346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9933460-8724834
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
115
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
324-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:9933460-Animals,
pubmed-meshheading:9933460-Antigens, CD95,
pubmed-meshheading:9933460-Apoptosis,
pubmed-meshheading:9933460-Immunity, Cellular,
pubmed-meshheading:9933460-Interferon-gamma,
pubmed-meshheading:9933460-Interleukin-2,
pubmed-meshheading:9933460-Interleukin-4,
pubmed-meshheading:9933460-Mice,
pubmed-meshheading:9933460-Mice, Inbred BALB C,
pubmed-meshheading:9933460-Mice, Inbred C3H,
pubmed-meshheading:9933460-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:9933460-Th1 Cells,
pubmed-meshheading:9933460-Tuberculosis, Pulmonary
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pubmed:year |
1999
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pubmed:articleTitle |
Apoptosis of Th1-like cells in experimental tuberculosis (TB).
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pubmed:affiliation |
National Centre for Cell Sciences, Ganeshkhind, Pune 411007, India.
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pubmed:publicationType |
Journal Article
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