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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-2-16
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pubmed:abstractText |
CD4+ mucosal T cells mediate the intestinal inflammation in Crohn's disease and may serve as an important target for immune intervention. Here we assessed the therapeutic effect of a synthetic mimetic of CD4 designed to mimic both the sequence and conformation of the complementarity-determining region 3 of murine CD4 V1 domain (rD-mPGPtide) in a mouse colitis model using immunization with 2,4,6-trinitrobenzene sulfonic acid (TNB). i.v. administration of the rD-mPGPtide but not control scrambled peptide could suppress severe inflammation in the chronic colitis mouse model. After treatment with the rD-mPGPtide, a striking improvement of diarrhea and acute wasting disease was observed with decreased mortality. Serum anti-TNB antibody titers, CD45RBlowCD4+ T cells in the lamina propria and IFN-gamma mRNA expression in the mucosa were significantly decreased with the rD-mPGPtide treatment. Anti-CD4 antibody also suppressed disease by depletion of CD45RBhighCD4+ T cells in the colonic mucosa. The observation that the synthetically engineered analogue of murine CD4 inhibits inflammation in a rodent disease model by different mechanisms than anti-CD4 antibody suggests that a human version of this peptide has potential therapeutic utility in CD4+ mucosal T cell-mediated intestinal inflammation in Crohn's disease.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Oligopeptides,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin, Bovine,
http://linkedlifedata.com/resource/pubmed/chemical/reverse D amino acid mouse...,
http://linkedlifedata.com/resource/pubmed/chemical/trinitrophenyl-bovine serum albumin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-2980
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pubmed:author |
pubmed-author:HayashiTT,
pubmed-author:HibiTT,
pubmed-author:IshiiHH,
pubmed-author:JamesonB ABA,
pubmed-author:MukaiMM,
pubmed-author:OkamotoSS,
pubmed-author:WatanabeMM,
pubmed-author:WatanabeNN,
pubmed-author:YajimaTT,
pubmed-author:YamadaTT,
pubmed-author:YamazakiMM
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
355-66
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9933118-Animals,
pubmed-meshheading:9933118-Antigens, CD4,
pubmed-meshheading:9933118-Base Sequence,
pubmed-meshheading:9933118-CD4-Positive T-Lymphocytes,
pubmed-meshheading:9933118-Crohn Disease,
pubmed-meshheading:9933118-Cytokines,
pubmed-meshheading:9933118-DNA Primers,
pubmed-meshheading:9933118-Disease Models, Animal,
pubmed-meshheading:9933118-Female,
pubmed-meshheading:9933118-Gene Expression,
pubmed-meshheading:9933118-Humans,
pubmed-meshheading:9933118-Immunity, Mucosal,
pubmed-meshheading:9933118-Immunosuppressive Agents,
pubmed-meshheading:9933118-Intestinal Mucosa,
pubmed-meshheading:9933118-Mice,
pubmed-meshheading:9933118-Mice, Inbred BALB C,
pubmed-meshheading:9933118-Oligopeptides,
pubmed-meshheading:9933118-RNA, Messenger,
pubmed-meshheading:9933118-Serum Albumin, Bovine
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pubmed:year |
1999
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pubmed:articleTitle |
A synthetic mimetic of CD4 is able to suppress disease in a rodent model of immune colitis.
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pubmed:affiliation |
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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