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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1999-5-20
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pubmed:abstractText |
Twin studies suggest that propensity to smoke and ability to quit smoking are influenced by genetic factors. As a means of investigating the risk of smoking associated with genetic polymorphisms in the dopamine transporter (SLC6A3) and the D2 dopamine receptor (DRD2) genes, a case-control study of 289 smokers and 233 nonsmoking controls and a case series analysis of smokers were conducted. A significant effect for SLC6A3 and a significant gene-gene interaction were found in a logistic regression model, indicating that individuals with SLC6A3-9 genotypes were significantly less likely to be smokers, especially if they also had DRD2-A2 genotypes. Smokers with SLC6A3-9 genotypes were also significantly less likely to have started smoking before 16 years of age and had prior smoking histories indicating a longer period of prior smoking cessation. This study provides preliminary evidence that the SLC6A3 gene may influence smoking initiation and nicotine dependence.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0278-6133
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
18
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
14-20
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:9925041-Adult,
pubmed-meshheading:9925041-African Continental Ancestry Group,
pubmed-meshheading:9925041-Age of Onset,
pubmed-meshheading:9925041-Aged,
pubmed-meshheading:9925041-Alleles,
pubmed-meshheading:9925041-Carrier Proteins,
pubmed-meshheading:9925041-Case-Control Studies,
pubmed-meshheading:9925041-Dopamine Plasma Membrane Transport Proteins,
pubmed-meshheading:9925041-European Continental Ancestry Group,
pubmed-meshheading:9925041-Female,
pubmed-meshheading:9925041-Genetic Predisposition to Disease,
pubmed-meshheading:9925041-Genotype,
pubmed-meshheading:9925041-Humans,
pubmed-meshheading:9925041-Male,
pubmed-meshheading:9925041-Membrane Glycoproteins,
pubmed-meshheading:9925041-Membrane Transport Proteins,
pubmed-meshheading:9925041-Middle Aged,
pubmed-meshheading:9925041-Nerve Tissue Proteins,
pubmed-meshheading:9925041-Receptors, Dopamine D2,
pubmed-meshheading:9925041-Smoking,
pubmed-meshheading:9925041-Smoking Cessation,
pubmed-meshheading:9925041-Statistics as Topic
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pubmed:year |
1999
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pubmed:articleTitle |
Evidence suggesting the role of specific genetic factors in cigarette smoking.
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pubmed:affiliation |
Lombardi Cancer Center, Georgetown University Medical Center, Washington, DC 20007-4104, USA. lermanc@gunet.georgetown.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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