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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5402
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pubmed:dateCreated |
1999-2-11
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pubmed:abstractText |
A carbapenem antibiotic, L-786,392, was designed so that the side chain that provides high-affinity binding to the penicillin-binding proteins responsible for bacterial resistance was also the structural basis for ameliorating immunopathology. Expulsion of the side chain upon opening of the beta-lactam ring retained antibacterial activity while safely expelling the immunodominant epitope. L-786,392 was well tolerated in animal safety studies and had significant in vitro and in vivo activities against methicillin- and vancomycin-resistant Staphylococci and vancomycin-resistant Enterococci.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Carbapenems,
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Dipeptidases,
http://linkedlifedata.com/resource/pubmed/chemical/Haptens,
http://linkedlifedata.com/resource/pubmed/chemical/Hexosyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Lactams,
http://linkedlifedata.com/resource/pubmed/chemical/Muramoylpentapeptide...,
http://linkedlifedata.com/resource/pubmed/chemical/Penicillin-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptidyl Transferases,
http://linkedlifedata.com/resource/pubmed/chemical/Thiazoles,
http://linkedlifedata.com/resource/pubmed/chemical/dipeptidase
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0036-8075
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pubmed:author |
pubmed-author:BlizzardT ATA,
pubmed-author:DiNinnoF PFP,
pubmed-author:DorsoKK,
pubmed-author:Epstein-ToneyJ HJH,
pubmed-author:GillC JCJ,
pubmed-author:HajduRR,
pubmed-author:HammondG GGG,
pubmed-author:HammondM LML,
pubmed-author:HeckJ VJV,
pubmed-author:HuberJJ,
pubmed-author:JacksonJ JJJ,
pubmed-author:KohlerJJ,
pubmed-author:KozarichJ WJW,
pubmed-author:KroppHH,
pubmed-author:LankasGG,
pubmed-author:PelakB ABA,
pubmed-author:RatcliffeR WRW,
pubmed-author:RosenHH,
pubmed-author:SilverLL,
pubmed-author:SundelofJ GJG,
pubmed-author:ThompsonRR,
pubmed-author:WildongerK JKJ,
pubmed-author:WilkeningR RRR
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
283
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
703-6
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:9924033-Animals,
pubmed-meshheading:9924033-Antibodies,
pubmed-meshheading:9924033-Bacterial Proteins,
pubmed-meshheading:9924033-Carbapenems,
pubmed-meshheading:9924033-Carrier Proteins,
pubmed-meshheading:9924033-Dipeptidases,
pubmed-meshheading:9924033-Drug Design,
pubmed-meshheading:9924033-Drug Resistance, Microbial,
pubmed-meshheading:9924033-Drug Resistance, Multiple,
pubmed-meshheading:9924033-Enterococcus,
pubmed-meshheading:9924033-Erythrocytes,
pubmed-meshheading:9924033-Haptens,
pubmed-meshheading:9924033-Hexosyltransferases,
pubmed-meshheading:9924033-Humans,
pubmed-meshheading:9924033-Immunodominant Epitopes,
pubmed-meshheading:9924033-Immunoglobulin G,
pubmed-meshheading:9924033-Lactams,
pubmed-meshheading:9924033-Lymphocyte Activation,
pubmed-meshheading:9924033-Macaca mulatta,
pubmed-meshheading:9924033-Mice,
pubmed-meshheading:9924033-Mice, Inbred DBA,
pubmed-meshheading:9924033-Microbial Sensitivity Tests,
pubmed-meshheading:9924033-Muramoylpentapeptide Carboxypeptidase,
pubmed-meshheading:9924033-Penicillin-Binding Proteins,
pubmed-meshheading:9924033-Peptidyl Transferases,
pubmed-meshheading:9924033-Staphylococcal Infections,
pubmed-meshheading:9924033-Staphylococcus,
pubmed-meshheading:9924033-Thiazoles
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pubmed:year |
1999
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pubmed:articleTitle |
Reduced immunotoxicity and preservation of antibacterial activity in a releasable side-chain carbapenem antibiotic.
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pubmed:affiliation |
Merck Research Laboratories, Rahway, NJ 07065, USA. hugh_rosen@merck.com
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pubmed:publicationType |
Journal Article
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