Linked Life Data

9922041

Source:http://linkedlifedata.com/resource/pubmed/id/9922041

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
1999-5-13
pubmed:abstractText
Levels of accumulation of methotrexate polyglutamates were measured in vitro in lymphoblasts obtained at diagnosis from children with B-progenitor cell acute lymphoblastic leukemia (pro-B ALL). They were compared to numerical and structural chromosomal abnormalities present in these leukemic cells. In a series of 95 patients, the percent with high lymphoblast methotrexate polyglutamate levels increased with the increase in modal number of total chromosomes (p<0.001). Thus, lymphoblast methotrexate polyglutamate accumulation appeared to be closely linked to the extent of hyperdiploidy in childhood pro-B ALL. Lymphoblasts from 35 (88%) of the 40 children with hyperdiploid (>50 chromosomes) and 23 (88%) of 26 with hyperdiploid (DNA Index >1.16) pro-B ALL accumulated high levels of methotrexate polyglutamate, suggesting that they were more sensitive to methotrexate cytotoxicity. While children with hyperdiploid (DNA Index >1.16) pro-B ALL have a good prognosis, those with trisomies of both chromosomes 4 and 10, almost all of whom are hyperdiploid, have an even better outcome. There was no significant difference in methotrexate polyglutamate levels in lymphoblasts from 19 children with and 21 without trisomies of both chromosomes 4 and 10 (p = 0.25). The improved response to multi-agent chemotherapy conferred by the presence of trisomies of both chromosomes 4 and 10 in such patients may be due to increased sensitivity of their lymphoblasts to one or more anti-leukemic agents in addition to methotrexate.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1042-8194
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
507-19
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:9922041-Adolescent, pubmed-meshheading:9922041-Aneuploidy, pubmed-meshheading:9922041-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:9922041-Bone Marrow, pubmed-meshheading:9922041-Child, pubmed-meshheading:9922041-Child, Preschool, pubmed-meshheading:9922041-Chromosomes, Human, Pair 10, pubmed-meshheading:9922041-Chromosomes, Human, Pair 4, pubmed-meshheading:9922041-Female, pubmed-meshheading:9922041-Folic Acid, pubmed-meshheading:9922041-Humans, pubmed-meshheading:9922041-Male, pubmed-meshheading:9922041-Methotrexate, pubmed-meshheading:9922041-Neoplastic Stem Cells, pubmed-meshheading:9922041-Peptide Synthases, pubmed-meshheading:9922041-Polyglutamic Acid, pubmed-meshheading:9922041-Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:9922041-Prognosis, pubmed-meshheading:9922041-Trisomy
pubmed:year
1998
pubmed:articleTitle
Accumulation of methotrexate polyglutamates, ploidy and trisomies of both chromosomes 4 and 10 in lymphoblasts from children with B-progenitor cell acute lymphoblastic leukemia: a Pediatric Oncology Group Study.
pubmed:affiliation
The Penny Cole Hematology Research Laboratory, McGill University - Montreal Children's Hospital Research Institute, Quebec, Canada.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't, Multicenter Study