| pubmed-article:9920797 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9920797 | lifeskim:mentions | umls-concept:C0039350 | lld:lifeskim |
| pubmed-article:9920797 | lifeskim:mentions | umls-concept:C0004492 | lld:lifeskim |
| pubmed-article:9920797 | lifeskim:mentions | umls-concept:C0074565 | lld:lifeskim |
| pubmed-article:9920797 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:9920797 | lifeskim:mentions | umls-concept:C0030011 | lld:lifeskim |
| pubmed-article:9920797 | lifeskim:mentions | umls-concept:C0079411 | lld:lifeskim |
| pubmed-article:9920797 | lifeskim:mentions | umls-concept:C0063235 | lld:lifeskim |
| pubmed-article:9920797 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:9920797 | pubmed:dateCreated | 1999-3-1 | lld:pubmed |
| pubmed-article:9920797 | pubmed:abstractText | Hypotaurine is oxidized to taurine by singlet oxygen (1O2) generated with methylene blue used as a photosensitizer. The oxidation rate increases in the presence of deuterium oxide as expected for the involvement of 1O2. Addition of the 1O2 quencher azide also produced an activating effect in contrast with the expected inhibition. Azidyl radicals produced by the oxidation of azide by the horseradish peroxidase/hydrogen peroxide system stimulate the oxidation of the added hypotaurine. It is concluded that azide competes with hypotaurine for 1O2 generating the azidyl radical which is a strong one-electron oxidant transfer of the radical to hypotaurine. The hypotaurine radical is then converted into taurine, possibly through the disulfone intermediate. Formation of the sulfonic hydroperoxide is the possible intermediate in the absence of azide. The finding that the azidyl radical efficiently oxidizes hypotaurine to its metabolic product taurine raises the expectation of hypotaurine being a valuable scavenger of endogenous and exogenous radicals. | lld:pubmed |
| pubmed-article:9920797 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9920797 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920797 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9920797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920797 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9920797 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9920797 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:9920797 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:9920797 | pubmed:author | pubmed-author:PecciLL | lld:pubmed |
| pubmed-article:9920797 | pubmed:author | pubmed-author:CostaMM | lld:pubmed |
| pubmed-article:9920797 | pubmed:author | pubmed-author:AntonucciAA | lld:pubmed |
| pubmed-article:9920797 | pubmed:author | pubmed-author:CavalliniDD | lld:pubmed |
| pubmed-article:9920797 | pubmed:author | pubmed-author:MontefoschiGG | lld:pubmed |
| pubmed-article:9920797 | pubmed:copyrightInfo | Copyright 1999 Academic Press. | lld:pubmed |
| pubmed-article:9920797 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9920797 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:9920797 | pubmed:volume | 254 | lld:pubmed |
| pubmed-article:9920797 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9920797 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9920797 | pubmed:pagination | 661-5 | lld:pubmed |
| pubmed-article:9920797 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:9920797 | pubmed:meshHeading | pubmed-meshheading:9920797-... | lld:pubmed |
| pubmed-article:9920797 | pubmed:meshHeading | pubmed-meshheading:9920797-... | lld:pubmed |
| pubmed-article:9920797 | pubmed:meshHeading | pubmed-meshheading:9920797-... | lld:pubmed |
| pubmed-article:9920797 | pubmed:meshHeading | pubmed-meshheading:9920797-... | lld:pubmed |
| pubmed-article:9920797 | pubmed:meshHeading | pubmed-meshheading:9920797-... | lld:pubmed |
| pubmed-article:9920797 | pubmed:meshHeading | pubmed-meshheading:9920797-... | lld:pubmed |
| pubmed-article:9920797 | pubmed:meshHeading | pubmed-meshheading:9920797-... | lld:pubmed |
| pubmed-article:9920797 | pubmed:meshHeading | pubmed-meshheading:9920797-... | lld:pubmed |
| pubmed-article:9920797 | pubmed:meshHeading | pubmed-meshheading:9920797-... | lld:pubmed |
| pubmed-article:9920797 | pubmed:year | 1999 | lld:pubmed |
| pubmed-article:9920797 | pubmed:articleTitle | Oxidation of hypotaurine to taurine with photochemically generated singlet oxygen: the effect of azide. | lld:pubmed |
| pubmed-article:9920797 | pubmed:affiliation | Centro di Studio sulla Biologia Molecolare del CNR, Università di Roma "La Sapienza,", Rome, Italy. lpecci@uniroma1.it | lld:pubmed |
| pubmed-article:9920797 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9920797 | lld:pubmed |
