Linked Life Data

9920797

Source:http://linkedlifedata.com/resource/pubmed/id/9920797

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-3-1
pubmed:abstractText
Hypotaurine is oxidized to taurine by singlet oxygen (1O2) generated with methylene blue used as a photosensitizer. The oxidation rate increases in the presence of deuterium oxide as expected for the involvement of 1O2. Addition of the 1O2 quencher azide also produced an activating effect in contrast with the expected inhibition. Azidyl radicals produced by the oxidation of azide by the horseradish peroxidase/hydrogen peroxide system stimulate the oxidation of the added hypotaurine. It is concluded that azide competes with hypotaurine for 1O2 generating the azidyl radical which is a strong one-electron oxidant transfer of the radical to hypotaurine. The hypotaurine radical is then converted into taurine, possibly through the disulfone intermediate. Formation of the sulfonic hydroperoxide is the possible intermediate in the absence of azide. The finding that the azidyl radical efficiently oxidizes hypotaurine to its metabolic product taurine raises the expectation of hypotaurine being a valuable scavenger of endogenous and exogenous radicals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0006-291X
pubmed:author
pubmed:copyrightInfo
Copyright 1999 Academic Press.
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
254
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
661-5
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1999
pubmed:articleTitle
Oxidation of hypotaurine to taurine with photochemically generated singlet oxygen: the effect of azide.
pubmed:affiliation
Centro di Studio sulla Biologia Molecolare del CNR, Università di Roma "La Sapienza,", Rome, Italy. lpecci@uniroma1.it
pubmed:publicationType
Journal Article