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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1977-1-28
|
| pubmed:abstractText |
l-Propranolol was found to protect mice from hyperbaric oxygen-induced seizures. The disposition of effective doses of propranolol isomers in mice was followed using stereospecific antibodies with a radioimmunoassay procedure. Serum and tissue concentrations were determined and correlated with the protective effect. Following racemic administration, there were no differences in serum disposition of d- and l-propranolol, although there was initially a preferential uptake of the 1-isomer both into cardiac and brain tissue. The d-isomer exerted synergistic action on the 1-isomer protective effect.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
0014-2999
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
93-100
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:991931-Animals,
pubmed-meshheading:991931-Drug Synergism,
pubmed-meshheading:991931-Hyperbaric Oxygenation,
pubmed-meshheading:991931-Male,
pubmed-meshheading:991931-Mice,
pubmed-meshheading:991931-Propranolol,
pubmed-meshheading:991931-Radioimmunoassay,
pubmed-meshheading:991931-Seizures,
pubmed-meshheading:991931-Stereoisomerism
|
| pubmed:year |
1976
|
| pubmed:articleTitle |
Disposition of propranolol isomers in mice.
|
| pubmed:publicationType |
Journal Article
|