Linked Life Data

9917868

Source:http://linkedlifedata.com/resource/pubmed/id/9917868

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-2-5
pubmed:abstractText
The cytokines interleukin (IL)-1, IL-6, and tumor necrosis factor (TNF)-alpha induce increases in body temperature via direct and indirect actions on the brain and are believed to act as endogenous pyrogens. We studied the mechanisms of action of these cytokines on fever in rats. Local administration of lipopolysaccharide (LPS) into a subcutaneous air pouch elicits marked fever, accompanied by increases in the levels of TNF-alpha, IL-1, and IL-6 in the pouch, but only IL-6 in the plasma. Thus, TNF-alpha and IL-1 probably act locally to stimulate the release of a secondary circulating mediator(s) (e.g., IL-6) that can interact with the brain. Neural afferents have also been implicated in relaying messages to the brain. Pyrogenic responses are reportedly attenuated by subdi-aphragmatic vagotomy; however, we failed to observe inhibition of fever in vagotomized rats injected with either LPS or a pyrogenic dose of IL-1, although behavioral responses are abolished.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:day
29
pubmed:volume
856
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
83-9
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
Cytokines and fever. Mechanisms and sites of action.
pubmed:affiliation
School of Biological Sciences, University of Manchester, UK. Gluheshi@man.ac.uk
pubmed:publicationType
Journal Article, Review