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rdf:type |
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|
lifeskim:mentions |
|
|
pubmed:issue |
11
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|
pubmed:dateCreated |
1999-2-17
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|
pubmed:abstractText |
Hereditary variations in the effects of benzodiazepine tranquilizers depending on the phenotype of an emotional stress reaction (ESR) are described. The membrane-receptor relationship showed differences between C57B1/6 with an "active" ESR phenotype and Balb/c with a "passive" ESR at the GABA benzodiazepine receptor complex level. The pharmacological results evidenced the selective anxiolytic properties of the novel drug aphobazole (2-[2-morpholyno)ethylthio]-5-ethoxybenzimidazole dihydrochloride) which produced an activating anxiolytic action in Balb/c mice whereas no behavioral changes were observed in C57B1/6 mice.
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pubmed:language |
rus
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
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|
pubmed:status |
MEDLINE
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|
pubmed:issn |
0869-6047
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|
pubmed:author |
pubmed-author:BadyshtovB ABA,
pubmed-author:BlednovIu AIuA,
pubmed-author:GaribovaT LTL,
pubmed-author:IarkovaM AMA,
pubmed-author:KolotilinskaiaN VNV,
pubmed-author:KozlovskaiaM MMM,
pubmed-author:NeznamovG GGG,
pubmed-author:Savel'evV LVL,
pubmed-author:SeredeninS BSB,
pubmed-author:Val'dmanE AEA,
pubmed-author:ViglinskaiaI VIV,
pubmed-author:VoroninaT ATA
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|
pubmed:issnType |
Print
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3-9
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|
pubmed:dateRevised |
2008-11-21
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|
pubmed:meshHeading |
pubmed-meshheading:9889697-Adult,
pubmed-meshheading:9889697-Animals,
pubmed-meshheading:9889697-Anti-Anxiety Agents,
pubmed-meshheading:9889697-Benzodiazepines,
pubmed-meshheading:9889697-Crosses, Genetic,
pubmed-meshheading:9889697-Humans,
pubmed-meshheading:9889697-Male,
pubmed-meshheading:9889697-Mice,
pubmed-meshheading:9889697-Mice, Inbred BALB C,
pubmed-meshheading:9889697-Mice, Inbred C57BL,
pubmed-meshheading:9889697-Motor Activity,
pubmed-meshheading:9889697-Pharmacogenetics,
pubmed-meshheading:9889697-Phenotype,
pubmed-meshheading:9889697-Psychopharmacology,
pubmed-meshheading:9889697-Rats,
pubmed-meshheading:9889697-Rats, Inbred Strains,
pubmed-meshheading:9889697-Statistics, Nonparametric,
pubmed-meshheading:9889697-Stress, Psychological
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
[The pharmacogenetic concept of the anxio-selective effect].
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|
pubmed:publicationType |
Journal Article,
Comparative Study,
English Abstract
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