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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1999-3-24
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ002687,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ002688,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ002689,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ002690,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ002691,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ002692,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ002693,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ002694,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ002695,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ002696,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ225171,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/AJ225174
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pubmed:abstractText |
Analysis of the humoral immune response of BALB/c mice to alpha(1-->3) dextran (Dex) reveals novel aspects of T cell-mediated control of 'type 2 thymus-independent' responses against polysaccharide antigens. The IgM and IgG antibody response, dominated by the J558 idiotype (Id), is controlled by Id-specific T cells. These regulatory T cells, for which the T cell clone 178-4 Ts with characterized TCR alpha and beta chain sequences is the prototype, expand in all BALB/c mice upon immunization with Dex. They suppress in a cognate interaction the expansion of J558 Id-bearing B cells, committed for production of IgG antibodies. Furthermore they provide a gate which precludes variability in the VH CDR3 region of IgG antibodies appearing occasionally in the periphery. The VH CDR3 region is the recognition element of 178-4 Ts analogous T cells but contributes little to affinity for the antigen. For recognition by 178-4 Ts cells not even minimal sequence deviations of the J558 Id peptide are allowed. The tight germline programmed complementarity between J558 Id-bearing Dex-specific B and J558 Id-specific 178-4 Ts analogous T cells leaves little room on both sides for ontogenetic variability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0953-8178
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1931-42
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9885915-Amino Acid Sequence,
pubmed-meshheading:9885915-Animals,
pubmed-meshheading:9885915-Antibody Affinity,
pubmed-meshheading:9885915-Antibody Specificity,
pubmed-meshheading:9885915-Base Sequence,
pubmed-meshheading:9885915-Dextrans,
pubmed-meshheading:9885915-Epitopes, T-Lymphocyte,
pubmed-meshheading:9885915-Immune Tolerance,
pubmed-meshheading:9885915-Immunoglobulin G,
pubmed-meshheading:9885915-Immunoglobulin Heavy Chains,
pubmed-meshheading:9885915-Immunoglobulin Idiotypes,
pubmed-meshheading:9885915-Immunoglobulin Variable Region,
pubmed-meshheading:9885915-Lymphocyte Cooperation,
pubmed-meshheading:9885915-Mice,
pubmed-meshheading:9885915-Mice, Inbred BALB C,
pubmed-meshheading:9885915-Mice, Inbred C57BL,
pubmed-meshheading:9885915-Mice, Nude,
pubmed-meshheading:9885915-Molecular Sequence Data,
pubmed-meshheading:9885915-T-Lymphocytes
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pubmed:year |
1998
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pubmed:articleTitle |
The J558 VH CDR3 region contributes little to antibody avidity; however, it is the recognition element for cognate T cell control of the alpha(1-->3) dextran-specific antibody response.
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pubmed:affiliation |
Institute for Immunology, University of Münster, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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