Linked Life Data

9879331

Source:http://linkedlifedata.com/resource/pubmed/id/9879331

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1999-1-14
pubmed:abstractText
FREQUENT MUTATIONS: Associated with the high turnover rate of the HIV, frequent inverse transcriptase errors lead to a wide range of possible mutations. Certain mutations can modify the response to antiretroviral agents. The development of resistant strains is mediated by the selection pressure of antiretroviral agents and occurs at a very variable rate depending on the antiretroviral agent used. TO LOWER THE RISK OF RESISTANCE: Persistent replication, whatever the cause, favors the emergence of resistant mutants. Thus the antiretroviral treatment must be initiated early and with the most powerful protocol possible in order to reduce viral replication as quickly as possible. CONTRIBUTION OF VIROLOGY TESTS: It is not always possible to predict the efficacy of antiviral agents from phenotyping and genotyping results. Their use is currently limited to cases of treatment failure. Their contribution in everyday clinical practice remains to be defined.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0755-4982
pubmed:author
pubmed:issnType
Print
pubmed:volume
27 Suppl 5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
18-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1998
pubmed:articleTitle
[Resistance to antiretroviral agents: mechanism and study methods].
pubmed:affiliation
Service de Maladies Infectieuses et Tropicales, Hôpital Pitié-Salpêtrière, Paris.
pubmed:publicationType
Journal Article, English Abstract