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rdf:type |
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lifeskim:mentions |
umls-concept:C0003161,
umls-concept:C0017337,
umls-concept:C0026882,
umls-concept:C0030232,
umls-concept:C0205314,
umls-concept:C0678215,
umls-concept:C0679622,
umls-concept:C1138842,
umls-concept:C1704259,
umls-concept:C1704735,
umls-concept:C1705987,
umls-concept:C1971630
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pubmed:issue |
1
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pubmed:dateCreated |
2000-3-31
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pubmed:abstractText |
By screening for new seed color mutations, we have identified a new gene, pale aleurone color1 (pac1), which when mutated causes a reduction in anthocyanin pigmentation. The pac1 gene is not allelic to any known anthocyanin biosynthetic or regulatory gene. The pac1-ref allele is recessive, nonlethal, and only reduces pigment in kernels, not in vegetative tissues. Genetic and molecular evidence shows that the pac1-ref allele reduces pigmentation by reducing RNA levels of the biosynthetic genes in the pathway. The mutant does not reduce the RNA levels of either of the two regulatory genes, b and c1. Introduction of an anthocyanin structural gene promoter (a1) driving a reporter gene into maize aleurones shows that pac1-ref kernels have reduced expression resulting from the action of the a1 promoter. Introduction of the reporter gene with constructs that express the regulatory genes b and c1 or the phlobaphene pathway regulator p shows that this reduction in a1-driven expression occurs in both the presence and absence of these regulators. Our results imply that pac1 is required for either b/c1 or p activation of anthocyanin biosynthetic gene expression and that pac1 acts independently of these regulatory genes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-1532784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-1577278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-15957214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-16594066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-1674607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-17247587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-17248508,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-17788612,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-1849854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-2369901,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-2535537,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-2674946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-3006070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-3753432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-6091052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-7827497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-8305872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-8313474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-8647404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-8807310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-9144964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-9192870,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-9611220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/9878628-9625696
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1040-4651
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5-14
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pubmed:dateRevised |
2010-9-10
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pubmed:meshHeading |
pubmed-meshheading:9878628-Alleles,
pubmed-meshheading:9878628-Anthocyanins,
pubmed-meshheading:9878628-Chromosome Mapping,
pubmed-meshheading:9878628-Gene Expression Regulation, Plant,
pubmed-meshheading:9878628-Genes, Reporter,
pubmed-meshheading:9878628-Mutation,
pubmed-meshheading:9878628-Pigmentation,
pubmed-meshheading:9878628-Promoter Regions, Genetic,
pubmed-meshheading:9878628-Zea mays
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pubmed:year |
1999
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pubmed:articleTitle |
A mutation in the pale aleurone color1 gene identifies a novel regulator of the maize anthocyanin pathway.
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pubmed:affiliation |
Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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