Linked Life Data

987847

Source:http://linkedlifedata.com/resource/pubmed/id/987847

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11 Pt. 2
pubmed:dateCreated
1976-12-23
pubmed:abstractText
One of the earliest events following the administration of estradiol to ovariectomized rats is an increase in transfer RNA (tRNA) methyltransferase activity activity of the uterus. Ovariectomy diminishes by about one-half the capacity of extracts of uteri to introduce methyl groups in vitro into heterologous tRNA. Administration of estradiol to ovariectomized animals restores the tRNA methyltransferase capacity to normal. Alterations in the population of uterine serine tRNA were also observed following ovariectomy. These findings represent reversible qualitative changes produced by a hormone in the target tissue. Whether the tRNA's are involved in regulating hormone-induced protein synthesis was investigated by studying the estrogen-induced ovalbumin synthesis in immature chick oviducts. tRNA's from oviducts of estrogen-stimulated chicks or from oviducts of laying hens produced an enhanced stimulation of ovalbumin synthesis in vitro compared with tRNA's from oviducts of immature chicks that were withdrawn from estrogen stimulation (these chicks do not synthesize ovalbumin). Some of these hormone-induced alterations may be of importance in understanding the molecular mechanisms of estrogen action on gene expression. During these studies, we have observed a novel effect of the administration of the carcinogen, ethionine, in the immature chicks. Ethionine induces ovalbumin and conalbumin synthesis in immature chick oviducts that were withdrawn from estrogen for 3 to 4 weeks following primary estrogen stimulation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0008-5472
pubmed:author
pubmed:issnType
Print
pubmed:volume
36
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4320-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
A mechanism of estrogen action on gene expression at the level of translation.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.