| pubmed-article:9874498 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:9874498 | lifeskim:mentions | umls-concept:C0005595 | lld:lifeskim |
| pubmed-article:9874498 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:9874498 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:9874498 | lifeskim:mentions | umls-concept:C1332709 | lld:lifeskim |
| pubmed-article:9874498 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:9874498 | pubmed:dateCreated | 1999-1-22 | lld:pubmed |
| pubmed-article:9874498 | pubmed:abstractText | CD28 costimulatory signals are required for T-cell proliferation and lymphokine production. In this work, the functional conservation of CD28 was studied in avian gammadelta T cells. The avian CD28 molecule is expressed on all alphabeta T cells and is capable of giving a costimulatory signal. Most peripheral gammadelta T cells are CD28 negative; however, we identified a CD28-positive gammadelta T-cell subset from peripheral blood comprising about 12% of gammadelta T cells. The peripheral CD28+ gammadelta T-cell subset included all CD8+ gammadelta T cells known to be a responding subset during activation. After polyclonal activation, the frequency of CD28+ gammadelta T cells was increased and the activation also up-regulated CD5, CD25 and major histocompatibility complex (MHC) class II molecules. These changes were detected after both polyclonal and antigen-specific T-cell activation. In addition, we also showed that CD28 can give a costimulatory signal to gammadelta T cells and that this signal leads to up-regulation of IL-2 and bcl-x transcripts. These results indicate that the function of CD28 is evolutionarily conserved and can already be detected in avian gammadelta T cells. | lld:pubmed |
| pubmed-article:9874498 | pubmed:language | eng | lld:pubmed |
| pubmed-article:9874498 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9874498 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:9874498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9874498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9874498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9874498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9874498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9874498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9874498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9874498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9874498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:9874498 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:9874498 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:9874498 | pubmed:issn | 0300-9475 | lld:pubmed |
| pubmed-article:9874498 | pubmed:author | pubmed-author:LassilaOO | lld:pubmed |
| pubmed-article:9874498 | pubmed:author | pubmed-author:KoskelaKK | lld:pubmed |
| pubmed-article:9874498 | pubmed:author | pubmed-author:ArstilaT PTP | lld:pubmed |
| pubmed-article:9874498 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:9874498 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:9874498 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:9874498 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:9874498 | pubmed:pagination | 635-41 | lld:pubmed |
| pubmed-article:9874498 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
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| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:meshHeading | pubmed-meshheading:9874498-... | lld:pubmed |
| pubmed-article:9874498 | pubmed:year | 1998 | lld:pubmed |
| pubmed-article:9874498 | pubmed:articleTitle | Costimulatory function of CD28 in avian gammadelta T cells is evolutionarily conserved. | lld:pubmed |
| pubmed-article:9874498 | pubmed:affiliation | Turku Immunology Centre and Department of Medical Microbiology, Turku University, Finland. | lld:pubmed |
| pubmed-article:9874498 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:9874498 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:9874498 | lld:pubmed |
