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pubmed-article:9873398pubmed:abstractTextMAdCAM-1 specifically binds the lymphocyte integrin alpha 4 beta 7 and participates in the homing of leukocytes to intestinal mucosal sites. The LDT sequence located on the CD loop of MAdCAM-1 is an important binding site for MAdCAM-1/alpha 4 beta 7 interactions. N-Terminus acylation of the LDT motif and modification of the C-terminus carboxamide with amines led to low micromolar MAdCAM-1 inhibitors.lld:pubmed
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pubmed-article:9873398pubmed:articleTitleNovel modified tripeptide inhibitors of alpha 4 beta 7 mediated lymphoid cell adhesion to MAdCAM-1.lld:pubmed
pubmed-article:9873398pubmed:affiliationLeukoSite, Inc., Cambridge, MA 02142, USA.lld:pubmed
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