|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
13
|
|
pubmed:dateCreated |
1999-1-29
|
|
pubmed:abstractText |
MAdCAM-1 specifically binds the lymphocyte integrin alpha 4 beta 7 and participates in the homing of leukocytes to intestinal mucosal sites. The LDT sequence located on the CD loop of MAdCAM-1 is an important binding site for MAdCAM-1/alpha 4 beta 7 interactions. N-Terminus acylation of the LDT motif and modification of the C-terminus carboxamide with amines led to low micromolar MAdCAM-1 inhibitors.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
7
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1601-6
|
|
pubmed:dateRevised |
2005-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:9873398-Cell Adhesion,
pubmed-meshheading:9873398-Humans,
pubmed-meshheading:9873398-Immunoglobulins,
pubmed-meshheading:9873398-Integrins,
pubmed-meshheading:9873398-Lymphoma, B-Cell,
pubmed-meshheading:9873398-Mucoproteins,
pubmed-meshheading:9873398-Oligopeptides,
pubmed-meshheading:9873398-Receptors, Lymphocyte Homing,
pubmed-meshheading:9873398-Structure-Activity Relationship,
pubmed-meshheading:9873398-Tumor Cells, Cultured
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Novel modified tripeptide inhibitors of alpha 4 beta 7 mediated lymphoid cell adhesion to MAdCAM-1.
|
|
pubmed:affiliation |
LeukoSite, Inc., Cambridge, MA 02142, USA.
|
|
pubmed:publicationType |
Journal Article
|
