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9873377
Source:
http://linkedlifedata.com/resource/pubmed/id/9873377
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Object
rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0114835
,
umls-concept:C0599473
,
umls-concept:C1510827
pubmed:issue
12
pubmed:dateCreated
1999-2-1
pubmed:abstractText
PD 108635 (1) was identified as a potent dopamine D4 ligand and we wanted to replace the benzylic alcohol with a metabolically more stable moiety. Investigations led to the discovery of a series of isoindolinones having D4 affinity.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Drd4 protein, rat
,
http://linkedlifedata.com/resource/pubmed/chemical/Indoles
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D2
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Dopamine D4
,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Serotonin
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0960-894X
pubmed:author
pubmed-author:BelliottiT RTR
,
pubmed-author:BootaAA
,
pubmed-author:CorbinA EAE
,
pubmed-author:HeffnerT GTG
,
pubmed-author:KestenS RSR
,
pubmed-author:PugsleyT ATA
,
pubmed-author:RubinJ RJR
,
pubmed-author:WhetzelS ZSZ
,
pubmed-author:WoodT ETE
,
pubmed-author:WustrowD JDJ
,
pubmed-author:ZoskiK TKT
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1499-502
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:9873377-Animals
,
pubmed-meshheading:9873377-Indoles
,
pubmed-meshheading:9873377-Motor Activity
,
pubmed-meshheading:9873377-Rats
,
pubmed-meshheading:9873377-Receptors, Dopamine D2
,
pubmed-meshheading:9873377-Receptors, Dopamine D4
,
pubmed-meshheading:9873377-Receptors, Serotonin
,
pubmed-meshheading:9873377-Stereoisomerism
,
pubmed-meshheading:9873377-Structure-Activity Relationship
,
pubmed-meshheading:9873377-X-Ray Diffraction
pubmed:year
1998
pubmed:articleTitle
Isoindolinone enantiomers having affinity for the dopamine D4 receptor.
pubmed:affiliation
Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Co., Ann Arbor, MI 48105, USA.
pubmed:publicationType
Journal Article