|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1999-1-25
|
|
pubmed:abstractText |
Streptozotocin (STZ)-induced diabetic animals are vulnerable to cold stress. Uncoupling proteins (UCPs) play an important role in regulating thermogenesis. We investigated the gene expressions of UCPs in brown adipose tissue (BAT), white adipose tissue (WAT), liver and gastrocnemius muscle of STZ-diabetic rats using Northern blot. UCP-1, -2 and -3 mRNA expressions in BAT were all remarkably lower in STZ-diabetic rats than those in control rats. Both UCP-2 and -3 gene expressions in gastrocnemius muscle were substantially elevated in STZ-diabetic rats and insulin treatment restored UCP gene expressions to normal levels. These results suggest that in STZ-diabetic rats, the overexpression of UCP-2 and UCP-3 in skeletal muscle provides a defense against hypothermogenesis caused by decreased UCPs in BAT.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitochondrial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Streptozocin,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein 2,
http://linkedlifedata.com/resource/pubmed/chemical/mitochondrial uncoupling protein 3
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
pubmed-author:GiacobinoJ PJP,
pubmed-author:HiranoTT,
pubmed-author:InoueSS,
pubmed-author:KageyamaHH,
pubmed-author:KashibaMM,
pubmed-author:KashiwaTT,
pubmed-author:NambaYY,
pubmed-author:NemotoKK,
pubmed-author:OkaJJ,
pubmed-author:OsakaTT,
pubmed-author:RicquierDD,
pubmed-author:SugaAA
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
4
|
|
pubmed:volume |
440
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
450-3
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:9872420-Adipose Tissue, Brown,
pubmed-meshheading:9872420-Animals,
pubmed-meshheading:9872420-Carrier Proteins,
pubmed-meshheading:9872420-Diabetes Mellitus, Experimental,
pubmed-meshheading:9872420-Gene Expression,
pubmed-meshheading:9872420-Insulin,
pubmed-meshheading:9872420-Ion Channels,
pubmed-meshheading:9872420-Liver,
pubmed-meshheading:9872420-Male,
pubmed-meshheading:9872420-Membrane Proteins,
pubmed-meshheading:9872420-Membrane Transport Proteins,
pubmed-meshheading:9872420-Mitochondrial Proteins,
pubmed-meshheading:9872420-Muscle, Skeletal,
pubmed-meshheading:9872420-Proteins,
pubmed-meshheading:9872420-RNA, Messenger,
pubmed-meshheading:9872420-Rats,
pubmed-meshheading:9872420-Rats, Sprague-Dawley,
pubmed-meshheading:9872420-Streptozocin
|
|
pubmed:year |
1998
|
|
pubmed:articleTitle |
Increased uncoupling protein-2 and -3 gene expressions in skeletal muscle of STZ-induced diabetic rats.
|
|
pubmed:affiliation |
Division of Geriatric Health and Nutrition, National Institute of Health and Nutrition, Tokyo, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
