Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1999-1-14
|
| pubmed:abstractText |
New non-cytotoxic taxanes synthesized from 10-deacetylbaccatin III and special hydrophobic acylating agents show remarkable MDR reversal activity (< or = 99.8%) against drug-resistant human breast cancer cells when co-administered with paclitaxel or doxorubicin. This activity is ascribed to the highly efficient blocking of P-glycoprotein efflux by these new taxanes.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
20
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
189-94
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:9871652-Animals,
pubmed-meshheading:9871652-Dose-Response Relationship, Drug,
pubmed-meshheading:9871652-Drug Resistance, Multiple,
pubmed-meshheading:9871652-Humans,
pubmed-meshheading:9871652-P-Glycoprotein,
pubmed-meshheading:9871652-Structure-Activity Relationship,
pubmed-meshheading:9871652-Taxoids,
pubmed-meshheading:9871652-Triterpenes,
pubmed-meshheading:9871652-Tumor Cells, Cultured
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
New taxanes as highly efficient reversal agents for multidrug resistance in cancer cells.
|
| pubmed:affiliation |
Department of Chemistry, State University of New York at Stony Brook 11794-3400, USA.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
|