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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1999-1-14
|
| pubmed:abstractText |
Preliminary results of a modelling study of both steroidal and non-steroidal inhibitors of 5 alpha-reductase (5AR) are described in order to elucidate the essential structural requirements needed for the design of novel non-steroidal inhibitors. The study suggests that: (i) there is a requirement for groups to mimic the C(3) = O of the steroid substrate A-ring; (ii) the area of the active site about the C(17)-OH position of the substrate does not appear to possess hydrogen bonding groups and is unrestricted.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
3
|
| pubmed:volume |
8
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
409-14
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:9871588-Cholestenone 5 alpha-Reductase,
pubmed-meshheading:9871588-Enzyme Inhibitors,
pubmed-meshheading:9871588-Hydrogen Bonding,
pubmed-meshheading:9871588-Molecular Structure,
pubmed-meshheading:9871588-Oxidoreductases,
pubmed-meshheading:9871588-Structure-Activity Relationship
|
| pubmed:year |
1998
|
| pubmed:articleTitle |
Structure activity relationship study of known inhibitors of the enzyme 5 alpha-reductase (5AR).
|
| pubmed:affiliation |
School of Applied Chemistry, Kingston University, Surrey. CH_S534@KINGSTON.AC.UK
|
| pubmed:publicationType |
Journal Article
|