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rdf:type |
|
|
lifeskim:mentions |
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|
pubmed:issue |
8
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|
pubmed:dateCreated |
1999-1-26
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|
pubmed:abstractText |
A series of leinamycin derivatives were synthesized and evaluated for antitumor activity. Modifications at C-8 and C-9 positions revealed a broad structure-activity relationship in vitro and some derivatives showed potent antiproliferative activity against HeLa S3 cells.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Apr
|
|
pubmed:issn |
0960-894X
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|
pubmed:author |
|
|
pubmed:issnType |
Print
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|
pubmed:day |
21
|
|
pubmed:volume |
8
|
|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
909-12
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pubmed:dateRevised |
2004-11-17
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|
pubmed:meshHeading |
pubmed-meshheading:9871510-Antibiotics, Antineoplastic,
pubmed-meshheading:9871510-Cell Division,
pubmed-meshheading:9871510-HeLa Cells,
pubmed-meshheading:9871510-Humans,
pubmed-meshheading:9871510-Indicators and Reagents,
pubmed-meshheading:9871510-Lactams,
pubmed-meshheading:9871510-Macrolides,
pubmed-meshheading:9871510-Molecular Conformation,
pubmed-meshheading:9871510-Molecular Structure,
pubmed-meshheading:9871510-Structure-Activity Relationship,
pubmed-meshheading:9871510-Thiazoles,
pubmed-meshheading:9871510-Thiones
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|
pubmed:year |
1998
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|
pubmed:articleTitle |
Synthesis and antitumor activity of leinamycin derivatives: modifications of C-8 hydroxy and C-9 keto groups.
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|
pubmed:affiliation |
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
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pubmed:publicationType |
Journal Article
|
