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rdf:type |
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lifeskim:mentions |
umls-concept:C0012634,
umls-concept:C0017262,
umls-concept:C0033684,
umls-concept:C0035820,
umls-concept:C0086418,
umls-concept:C0140145,
umls-concept:C0185117,
umls-concept:C0475264,
umls-concept:C1332102,
umls-concept:C1415470,
umls-concept:C1527178,
umls-concept:C2911684
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pubmed:issue |
6
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|
pubmed:dateCreated |
1999-3-25
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|
pubmed:abstractText |
Human AP endonuclease 1 (HAP1) plays a major role in the repair of apurinic/apyrimidinic (AP) sites in cellular DNA by catalysing hydrolytic cleavage of the phosphodiester backbone 5' to the site. HAP1 is also known to be a potent reduction-oxidation (redox) factor, regulating the binding activity of a number of transcription factors. The purpose of the present study was to examine the expression of HAP-1 in a wide range of human tissues.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0309-0167
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pubmed:author |
pubmed-author:BarzilayGG,
pubmed-author:GatterK CKC,
pubmed-author:GeorgouliasVV,
pubmed-author:GiatromanolakiAA,
pubmed-author:HarrisA LAL,
pubmed-author:HicksonI DID,
pubmed-author:KaklamanisLL,
pubmed-author:KakolyrisSS,
pubmed-author:KanavarosPP,
pubmed-author:KoukourakisMM,
pubmed-author:NovoSS,
pubmed-author:TurleyHH
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pubmed:issnType |
Print
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pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
561-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:9870152-Antibodies,
pubmed-meshheading:9870152-Carbon-Oxygen Lyases,
pubmed-meshheading:9870152-Cell Nucleus,
pubmed-meshheading:9870152-Cytoplasm,
pubmed-meshheading:9870152-DNA Repair,
pubmed-meshheading:9870152-DNA-(Apurinic or Apyrimidinic Site) Lyase,
pubmed-meshheading:9870152-Endothelium, Vascular,
pubmed-meshheading:9870152-Humans,
pubmed-meshheading:9870152-Immunohistochemistry,
pubmed-meshheading:9870152-Muscle, Smooth, Vascular,
pubmed-meshheading:9870152-Tissue Distribution
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pubmed:year |
1998
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pubmed:articleTitle |
Expression and subcellular localization of human AP endonuclease 1 (HAP1/Ref-1) protein: a basis for its role in human disease.
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pubmed:affiliation |
Department of Cellular Science, John Radcliffe Hospital, University of Oxford.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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