Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1999-2-5
pubmed:abstractText
Dishevelled (Dsh/Dvl) proteins are known to mediate Wnt signaling by up-regulating beta-catenin levels and stimulating T cell factor (TCF)/LEF-1-dependent transcription. We have identified a new Dvl-mediated signaling pathway in that mouse Dvl proteins, when expressed in COS-7 cells, stimulate c-Jun-dependent transcription activity and the kinase activity of the c-Jun N-terminal kinase (JNK). The DEP domain of Dvl1 is essential for JNK activation. By contrast, all three conserved domains of Dvl, including DIX, PDZ, and DEP, are required for up-regulation of beta-catenin and for stimulation of LEF-1-mediated transcription in mammalian cells. Thus, Dvl can lead to two different signaling pathways. Furthermore, the small G proteins of Cdc42 or Rac1, which are involved in JNK activation by many stimuli, do not appear to play a major role in Dvl-mediated JNK activation, because the dominant negative mutants of Cdc42 and Rac1 could not inhibit Dvl-induced JNK activation. This suggests that Dvl may activate JNK via novel pathways.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing, http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent..., http://linkedlifedata.com/resource/pubmed/chemical/Catnb protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Cell Cycle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins, http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/JNK Mitogen-Activated Protein..., http://linkedlifedata.com/resource/pubmed/chemical/Lef1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Lymphoid Enhancer-Binding Factor 1, http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases, http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors, http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin, http://linkedlifedata.com/resource/pubmed/chemical/dishevelled proteins
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0021-9258
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
274
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
129-34
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:9867820-3T3 Cells, pubmed-meshheading:9867820-Adaptor Proteins, Signal Transducing, pubmed-meshheading:9867820-Animals, pubmed-meshheading:9867820-COS Cells, pubmed-meshheading:9867820-Calcium-Calmodulin-Dependent Protein Kinases, pubmed-meshheading:9867820-Cell Cycle Proteins, pubmed-meshheading:9867820-Cytoskeletal Proteins, pubmed-meshheading:9867820-DNA-Binding Proteins, pubmed-meshheading:9867820-Enzyme Activation, pubmed-meshheading:9867820-JNK Mitogen-Activated Protein Kinases, pubmed-meshheading:9867820-Lymphoid Enhancer-Binding Factor 1, pubmed-meshheading:9867820-Mice, pubmed-meshheading:9867820-Mitogen-Activated Protein Kinases, pubmed-meshheading:9867820-Phosphoproteins, pubmed-meshheading:9867820-Signal Transduction, pubmed-meshheading:9867820-Trans-Activators, pubmed-meshheading:9867820-Transcription, Genetic, pubmed-meshheading:9867820-Transcription Factors, pubmed-meshheading:9867820-Up-Regulation, pubmed-meshheading:9867820-beta Catenin
pubmed:year
1999
pubmed:articleTitle
Dishevelled proteins lead to two signaling pathways. Regulation of LEF-1 and c-Jun N-terminal kinase in mammalian cells.
pubmed:affiliation
Department of Pharmacology and Physiology and Department of Oncology, University of Rochester, Rochester, New York 14642-8711, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.