Linked Life Data

9864262

Source:http://linkedlifedata.com/resource/pubmed/id/9864262

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1999-1-27
pubmed:abstractText
The noncompetitive N-methyl-D-aspartate (NMDA) antagonists dizocilpine and phencyclidine cause behavioral changes in animals that can be blocked by antipsychotic agents, implicating NMDA receptors in the expression of schizophrenic symptoms. In the present study, we examined the effects of dizocilpine (0.1-3.0 mg/kg s.c.) on locomotor activity and on the expression of c-fos and hsp-70 immediate-early genes (IEGs) in mice. Results indicate that dizocilpine increases locomotor activity and selectively increases the expression of c-fos and hsp-70 in the posterior cingulate cortex. Haloperidol (0.01-0.1 mg/kg) and clozapine (0.6-1.25 mg/kg) block both the locomotor response and the increased IEG immunoreactivity induced by dizocilpine (0.6 mg/kg). The 5-HT2 antagonists ritanserin (0.06-0.25 mg/kg), ketanserin (0.03-0.12 mg/kg) and amesergide (0. 3-1.25 mg/kg) also significantly attenuated the locomotor response to dizocilpine. Haloperidol and clozapine suppressed the head weaving induced by dizocilpine, but ritanserin, as previously reported did not. Although some attenuation of the c-fos and hsp-70 immunoreactivity was seen with the 5-HT2 antagonists it was less pronounced than that induced by haloperidol or clozapine. In conclusion, 5-HT2 antagonists as well as antipsychotic compounds attenuate the locomotor response to dizocilpine in mice. Haloperidol and clozapine appear to be more effective, however, in attenuating the expression of c-fos and hsp-70 in the posterior cingulate gyrus than 5-HT2 antagonists ritanserin, ketanserin or amesergide. We thus have seen a dissociation in the capacity of compounds to alter the effects on behavior and IEG expression after dizocilpine administration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
287
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
839-46
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:9864262-Animals, pubmed-meshheading:9864262-Antipsychotic Agents, pubmed-meshheading:9864262-Behavior, Animal, pubmed-meshheading:9864262-Clozapine, pubmed-meshheading:9864262-Dizocilpine Maleate, pubmed-meshheading:9864262-Dose-Response Relationship, Drug, pubmed-meshheading:9864262-Excitatory Amino Acid Antagonists, pubmed-meshheading:9864262-Female, pubmed-meshheading:9864262-Gyrus Cinguli, pubmed-meshheading:9864262-HSP70 Heat-Shock Proteins, pubmed-meshheading:9864262-Haloperidol, pubmed-meshheading:9864262-Immediate-Early Proteins, pubmed-meshheading:9864262-Immunohistochemistry, pubmed-meshheading:9864262-Ketanserin, pubmed-meshheading:9864262-Mice, pubmed-meshheading:9864262-Motor Activity, pubmed-meshheading:9864262-Proto-Oncogene Proteins c-fos, pubmed-meshheading:9864262-Ritanserin, pubmed-meshheading:9864262-Serotonin Antagonists
pubmed:year
1998
pubmed:articleTitle
Effects of 5-hydroxytryptamine2 receptor antagonism on the behavioral activation and immediate early gene expression induced by dizocilpine.
pubmed:affiliation
Eli Lilly and Company Ltd., Windlesham,Surrey, UK. oneill_michael_f@lilly.com
pubmed:publicationType
Journal Article